Genes in the Wild: The Secret to Chimpanzee Survival

By: Haley Lussier, Madison Navega, and Madison Warren (Stonehill College, BIO323: Evolution, Spring 2025)

Did you know humans are most closely related to chimpanzees? Chimpanzees are remarkably diverse in their adaptation to different habitats, just like we are. Whether you are from Australia or the United States, your population can adapt to the habitat you are in. One cannot deny that change affects habitats, species, and the planet as a whole. Conservation biology has become a vital field for understanding and preserving biodiversity. One key concept in this field is local genetic adaptation, which ensures a species is well-suited to its environment and retains the potential to adapt over time. The recent Science article “Local genetic adaptation to habitat in wild chimpanzees,” by Dr. Harrison Ostridge and 73 coauthors, investigates the differences in the genetic makeup of wild chimpanzee populations to look for evidence that these differences provide an advantage in different environments. Dr. Ostridge completed this research as part of his Ph.D. dissertation at University College London, where he focused on population genomics and its relationship to disease adaptation.

A short podcast summarizing the article. Image of chimpanzee by Erwin Sieben: https://www.inaturalist.org/observations/198410009.
Continue reading “Genes in the Wild: The Secret to Chimpanzee Survival”

MHC molecular evolution in chimpanzees

By: Sarah Boles, Carly Russell, Tia Zephir, and Gabby Scarcella (Stonehill College, BIO323: Evolution, Spring 2021)

Have you ever wondered how your immune system just knows and acts on a variety of diseases? Especially now during COVID-19, it seems our immune systems are really being put to the test. The actions of your immune system are due to the major histocompatibility complex (MHC). In  a recent article in BMC Evolutionary Biology, researchers from the University of Geneva and the Biomedical Primate Research Center wanted to see if MHC genes are conserved and evolving similarly in Western chimpanzees (Pan troglodytes verus) and humans. The MHC region, referred to as Patr in chimpanzees and HLA in humans, is a family of genes that plays a key role in a population’s adaptive immunity. MHC diversity could affect a population’s survival because these genes code for proteins that help combat viral infections and protect the organism from harmful pathogens. MHC genes are classified as class I genes or class II genes, which differ in structure and function. The class I genes are named A, B, and C, and target viral invaders, whereas class II genes, such as DPB1, DQB1, DQA1, and DRB1, target parasitic and bacterial invaders. The objective of this study was to determine if the genetic diversity at different Patr genes is significantly reduced in present day Western chimpanzees due to a past bottleneck effect, which is defined as the sudden decrease of a population from natural causes. The researchers also compared human and chimpanzee genetic diversity to determine if MHC molecular evolution mechanisms were conserved between the two species.

Listen now and read more below:

A short podcast summarizing the article
Continue reading “MHC molecular evolution in chimpanzees”